This technology could potentially be used to generate T cell progenitors for adoptive therapy | Our experiments show a pivotal role for AA during human in vitro T cell development |
---|---|
PMID: 33462228 Free PMC article | American Society of Clinical Oncology |
PMID: 34117371 Free PMC article.
AA may enhance T cell proliferation and differentiation in a controlled, feeder-free environment containing Notch ligands and defined growth factors | Causes of anemia in patients with cancer |
---|---|
AA promotes the transition of proT1 to proT2 cells and of preT to DP T cells | We conclude that neither DLL4-expressing feeder cells nor feeder cell conditioned media are required for generating DP T cells from CB and G-CSF-mobilized HSCs and that generation and proliferation of proT and DP T cells are greatly improved by AA |
2 Department of Internal Medicine, Division of Hematology, Maastricht University Medical Center, and.
20Adoptive transfer of in vitro-generated human T cell progenitors seems a promising approach to accelerate T cell recovery in immunocompromised patients | Approach to the adult with anemia |
---|---|
2021 Jan 18;12 1 :430 | 3 Department of Toxicogenomics, School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands |
Disorders of blood cell production in clinical oncology.